The PPI network analysis results of the present study indicate that IGFBP1, SPARCL1, CDH2, ITIH2, F5, APOA2, TF, CP, FGA, SERPINC1, F2, and PLG participate in IGFBP processes to regulate IGF transport and uptake signaling pathways, and these DEGs might participate in this pathway to affect the invasion and metastasis of CRC. Here, PLG is linked to colorectal carcinoma.