NFKB1 and familial pancreatic carcinoma: Curcumin was shown to suppress growth of bladder and pancreatic cancer cell lines through the inhibition of NFKB1-regulated proinflammatory and proproliferative gene products PTGS2 [93] and CXCL8 [94] (Table 1); both CXCL8 and PTGS2 were also found to be downregulated in pancreatic cancer (Table 2).