PTGS2 and cancer: Furthermore, β-caryophyllene and β-caryophyllene oxide extracted from Aegle marmelos are suggested to possess anti-inflammatory potential and were demonstrated to induce apoptosis in cancer cells of diverse tissue origin, that is, lymphoma (i.e., haematological cancer) and neuroblastoma (i.e., nerve tissue neoplasm), through overexpression of the proapoptotic (ATM, BAK1, BAX, and CASP8/9) and underexpression of the antiapoptotic (BCL2, MDM2 proto-oncogene, and PTGS2) genes [110] (Table 1).