Furthermore, it was demonstrated by Takada and colleagues [89] that I3C (Table 1) blocks the expression of NFKB1-regulated prometastatic, proproliferation, and antiapoptotic gene products (i.e., AKT1, BCL2, BIRC2, BIRC5, CCND1, MMP9, PTGS2, TNF, and XIAP) in myeloid and leukemia cells. This evidence concerns the gene MMP9 and leukemia.