Tao et al. have reported that PRP-Exos can suppress apoptosis in a rat model of femoral head osteonecrosis via the Akt/Bad/Bcl-2 signaling pathway [31], while Iyer et al. revealed the ability of PRP-Exo treatment to promote functional recovery following muscle injury [32]. The gene discussed is AKT1; the disease is familial avascular necrosis of femoral head.