A prospective population-based Atherosclerosis Risk in Communities (ARIC) cohort study, after 9.6 years of the follow-up study, found that no significant association between intracellular monocyte MPO level and incident of cardiovascular events was found among 1465 patients without a history of PAD, myocardial infarction, or heart failure [60]. This evidence concerns the gene MPO and myocardial infarction.