TP53 and cancer: This amino acid change affects the structure of the protein and might thereby influences its function.33 The TP53 Pro72Arg variant shows varying allele-frequencies in different populations, according to the 1000 Genomes Project.34 Because of its high frequency in humans, the SNP TP53 Pro72Arg has been studied for its association with cancer risk and cancer development in a multitude of studies.19 Allele frequencies of this SNP are known to be different in European compared with Asian populations and the combination with ethnicity–specific genetic makeup could lead to different phenotypes.