AKT1 and osteosarcoma: In recent years, the study found that PI3K/AKt signal pathway exists in a variety of human tumors, including osteosarcoma expression disorders [41, 42]; the phosphorylated AKt (p-AKt) could influence its downstream target protein Bad (members of the family of the Bcl-2), caspase 9, and NF-κB, thus regulating cell proliferation, cell differentiation, and apoptosis.