To further clarify the reasons for the general low expression of the above-mentioned signature genes in adult renal tumors, we used the genes of the query signature, AQP2, CLDN19, DEFB1, KCNJ1, NAT8, HMGCS2, and TMPRSS2 (the average beta value for “UMOD” is not available for the majority of the samples in KICH, KIRC, and KIRP; KICH has no normal methylation data). This evidence concerns the gene AQP2 and kidney neoplasm.