CTNNB1 and Nephroblastoma: For example, some genetic biomarkers associated with Wilms tumors have been identified in approximately 1/3 of all Wilms tumors include WT1, CTNNB1, and WTX mutations or the loss of heterozygosity of the 1p, 1q, 11p15, and 16q chromosomes [10] affecting the normal embryonic development of the genitourinary tract.