In the present study, we demonstrated that rats with hyperandrogenic PCOS induced by continuous injection of large doses of DHEA manifested obvious inflammation and leptin resistance and that regular aerobic exercise under the Masashi swimming protocol [25] (which is a commonly used exercise protocol in animal models) ameliorated the inflammation, alleviated leptin resistance, improved the sex hormone metabolic disorder caused by hyperandrogenism, and promoted ovulation. The gene discussed is LEP; the disease is hyperandrogenism.