A recent study demonstrated that Atg7 knockdown in nutrient-starved HCC Hep3B cells inhibits autophagosome formation, whereas knockdown of Atg7 also decreased HCC cell proliferation and tumorigenesis in a murine HCC mouse model induced by activated RAS, suggesting that functional autophagy promotes HCC tumorigenesis [113]. Here, ATG7 is linked to hepatocellular carcinoma.