Furthermore, they identified a SNP in a region that forms CTCF-bound loops with Paired Immunoglobin Like Type 2 Receptor Alpha and Beta (PILRA, PILRB) and Stromal antigen 3 opposite strand (GATS) gene loci, which have been shown to be dysregulated in various brain structures affected by AD (Kikuchi et al., 2019). This evidence concerns the gene CTCF and Alzheimer disease.