NRF1 and Alzheimer disease: However, AD-specific gains in histone acetylation were enriched for CTCF and NRF1 motifs (Nativio et al., 2020) and AD-specific histone hyperacetylation overlapped with some GWAS-identified risk SNPs, which suggests that inappropriate chromosome looping contributes to AD etiology (Nativio et al., 2020).