TP63 and exstrophy-epispadias complex: Here, we will focus on two ectodermal dysplasias that are caused by missense mutations in the TP63 gene: ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome [EEC; OMIM #604292] and ankyloblepharon-ectodermal defects-cleft lip/palate syndrome [AEC; OMIM #106260] (Rinne et al., 2007).