CIBERSORT algorithm was applied for inferring the proportions of 22 immune cells in HBV-related HCC tissues, including B cells naïve, B cells memory, plasma cells, T cells CD8, T cells CD4 memory resting, T cells CD4 memory activated, T cells follicular helper, T cells regulatory (Tregs), T cells gamma delta, NK cells resting, NK cells activated, monocytes, macrophages M0, macrophages M1, macrophages M2, dendritic cells resting, dendritic cells activated, mast cells resting, mast cells activated, eosinophils and neutrophils (Figure 7A). This evidence concerns the gene CD4 and hepatocellular carcinoma.