The miR-183 cluster (miR-96/183)–foxo3 pair presented in this study revealed that its pathway may result in damage to the central nervous system (Li et al., 2010), immune impairment, or even cancer (Dambal et al., 2015; Ichiyama and Dong, 2019; Zou et al., 2019). The gene discussed is FOXO3; the disease is cancer.