Furthermore, HOXB5 expression was positively associated with leukocytosis [white blood cell (WBC) count > 30 × 109/L] and hyperleukocytosis (WBC count > 100 × 109/L), which were biomarkers for inferior prognosis (Liu et al., 2020; Figure 1E and Supplementary Figures 3A,B). This evidence concerns the gene HOXB5 and Increased total leukocyte count.