This revealed eleven distinct regions (R1-R11) with varying abundance of distinct lymphoid, myeloid and cancer cells, including: MHCII- or CD206+ Mf enriched (R2-R3), T cell dense (R4), TCF1+ CD8 T cell and DC2 enriched (R5), general T cell – DC2 rich (R6), T cell – MHCII+ activated Mf (R7), myeloid-rich with cancer cells (R8-9), as well as CEA+ tumor and tumor nest regions (R10-11) which were devoid of T cells (Figure 3A). The gene discussed is MRC1; the disease is cancer.