CEACAM5 and colon carcinoma: To this end, mice bearing MC38 colon carcinomas or KPC pancreatic adenocarcinomas engineered to express human carcinoembryonic antigen (CEA) were treated with CEA-TCB murine surrogate antibody and/or with anti-PD-L1 checkpoint inhibitor, both of which can synergize to promote enhanced CD8 T cell immunity (50, 57, 78, 79).