This revealed seven distinct region types with varying abundance of lymphoid, myeloid, blood vessels and cancer cells, including: (R2) blood vessel rich, (R3) CD4+ T cell and myeloid cell region with blood vessels, (R4) CD4 and CD8 T cell rich region with blood vessels, (R5) highly T cell and DC2 rich region with abundant blood vessels, as well as (R6) Mf rich and (R7) CEA+ tumor nest regions (Figure 6A). Here, CD4 is linked to neoplasm.