PADI2 and rheumatoid arthritis: This is important because the presence of polymorphisms in PADI2 could modulate the expression and enzymatic function, therefore relating not only with the serologic positivity to a wide repertoire of antibodies, but also with the activation of naive T cells in response to antigen or “self” antigens, and their subsequent proliferation and differentiation, involved in the pathogenesis and clinical diversification of RA.