Thus far, several studies have indicated that DCs contribute to the initiation of psoriasis through antigen-presenting molecules (e.g., major histocompatibility complex [MHC], MHCII, CD86, and CD40), cytokines (e.g., interferon [IFN], IL-1β, IL-23, and IL-6), and chemokine receptors (6, 11, 14). The gene discussed is IL1B; the disease is psoriasis.