Consistent with these findings, most psoriasis-related cytokines were also greatly reduced in mice pretreated with SBI (Figure S3G), especially Cxcl1, Cxcl2, S100a8 and Il6. Thus, topical application of ULK1 inhibitor SBI improved IMQ-mediated dermatitis in both a preventative and therapeutic manner with less infiltration of neutrophils. Here, S100A8 is linked to skin disorder.