S100A8 and psoriasis: Molecular analysis demonstrated a significant reduction in the transcripts of psoriasis-related proinflammatory mediators, including Th17 cytokines (Il17f, Il22), neutrophil chemoattractants (Cxcl1, Cxcl2), AMPs (S100a8, S100a9) and proinflammatory cytokines (Il1b, Tnf) (Figure 3F).