Infiltrated immune cells, in return, stimulate KCs, which undergo dysregulated proliferation and differentiation, and at the same time, produce more chemokines (such as CCL20, CXCL1, CXCL2 and CXCL8) and AMP (such as S100 proteins and β-defensins) to magnify the immune circuits responsible for the induction and maintenance of psoriasis. The gene discussed is CXCL8; the disease is psoriasis.