Canonical inflammasomes, assembled by sensor proteins (including pyrin domain containing related protein family (NLRP), absent in melanoma (AIM) 2, interferon-γ inducible factor (IFI) 16, RIG-I, and CARD-domain-containing (NLRC) 4), play key roles in immune surveillance of pathogens infections and danger signals by proteolytically activating caspases 1 and/or 11 (caspase-4/5 in humans) that cleaves interleukin-1β (IL-1β), interleukin-18 (IL-18) and the pore-forming protein gasdermin D (GSDMD), leading to cytokine maturation and pyroptosis (Table 1) (25, 26). This evidence concerns the gene GSDMD and infection.