HAVCR2 and neoplasm: Mechanismly, the checkpoint molecule, T cell immunoglobulin and mucin-containing molecule 3 (TIM-3) in DC cells restrains anti-tumor immunity through suppressing inflammasome activation; TIM-3-deficient DCs promote the recruitment of stem-like CD8+ TILs and boost antigen-specific immunity via increasing accumulation of reactive oxygen species resulting in driving inflammasome activation (111).