We found that unlike at d6, histopathological GvHD was evident at d21 (Figure 6A) with significant increases in periportal inflammation and lymphocyte infiltration with increased caspase-3 activity (Figure 6B) and VCAM-1 upregulation (Figure 6C) affirming that increased mRNA levels of VCAM-1 preceded increased translation of the molecule. Here, CASP3 is linked to graft versus host disease.