The most current generation CAR T cells, T cells redirected for universal cytokine-mediated killing (TRUCKS), have co-stimulatory molecules and are armed with transgenes to express a synthetic protein of interest such as immune stimulatory cytokines of IL-2, IL-5, IL-12 to exhibit an improved anti-tumor function and resistance to immunosuppressive tumor microenvironment (22, 23). This evidence concerns the gene IL5 and neoplasm.