CD38 is expressed in hematological malignancies, including acute B lymphoblastic leukemia (B-ALL), acute myeloid leukemia (AML), mantle cell lymphoma (MCL), CLL, multiple myeloma (MM) and NK/T cell leukemia (T-ALL) (55, 94, 102, 105, 130–132). This evidence concerns the gene CD38 and acute myeloid leukemia.