IFNG and infection: Infection with KRV induces a global innate immune upregulation detected in various lymphoid organs, such as the spleen, pancreatic lymph nodes, Peyer’s patches and thymus involving the induction of numerous proinflammatory cytokines, including IL-1ß, IFN-γ, and IL-12 3-5 days after infection, prior to insulitis and diabetes (30, 34, 35, 66).