SRC and neoplasm: Another study in multiple tumor cell lines (including HeLa, SYF, HEK-293T, MKN45, SNU16, BT20 and MB468) showed that RUNX3 may be phosphorylated by Src kinase, resulting in mislocalization; Src was predominantly localized in the cytoplasm but also found in nucleus, and when Src was inhibited by siRNAs, RUNX3 was able to translocate back to nucleus (37).