To elucidate the mechanism of LV-miR-130a-3p alleviating liver pathology in schistosomiasis, immunohistochemical (IHC) staining and qRT-PCR were used to detect the protein and mRNA expressions of α-SMA and Col I in LV-miR-130a-3p and LV-NC treated liver of mice infected with S. japonicum. Here, ACTA1 is linked to schistosomiasis.