In the following, we use the terms ‘IFN+ patient group’ and ‘IFN- patient group’ based on the enrichment defined using IFN I modules since we focus on IFN I responses, however the high redundancy within the enrichment in IFN II modules implied that that they refer to TB patients with both IFN I and IFN II signaling enrichment in 84% of the cases. Here, IFNA1 is linked to tuberculosis.