The findings were complemented by non-human primate studies which revealed that enrichment in IFN gene sets is not a result of time p.i. Finally, we determined that the gene signature from the IFN- TB patient group provided comparable, slightly higher sensitivity and specificity for overall diagnosis of TB, primarily because of better classification of IFN- TB patients from OD patients, and analyzed further mechanisms differentially regulated between subgroups of TB patients which should be further explored as new potential TB endotypes with different underlying host immune responses. The gene discussed is IFNA1; the disease is osteochondritis dissecans.