We observed the peak of the type I IFN response between the 20th and 42nd day p.i. Intriguingly, enrichment in IFN modules was independent from the disease status: between days 20 and 42 p.i., the majority of animals which developed active TB disease as well as those which remained asymptomatic presented strong enrichment in IFN gene sets (Figure 6, Supplementary Figure 10). Here, IFNA1 is linked to tuberculosis.