The WTBE I, WTBE II, and WTBE III each included at least one gene set which is related to mechanisms that have been previously described as important in TB disease and could lead to diverse clinical characteristics of TB among patients: (1) calcium reabsorption, (2) insulin secretion, and (3) amino acid (D-Arginine and D-ornithine)-metabolism (53–55). This evidence concerns the gene INS and tuberculosis.