Interestingly, despite IFN type I and type II signaling pathways being the most studied in the immune response to TB, we found that also IFN λ receptor gene (IFNLR1), but not IFN λ gene (IFNL) itself, which both belong to type III IFN signaling pathway was significantly overexpressed in IFN+ compared to IFN- TB patients or healthy (Supplementary Figures 7D, E). The gene discussed is IFNLR1; the disease is tuberculosis.