Considering the heterogeneity in the clinical course of patients with neuroinflammatory and neurodegenerative diseases, we investigated the presence of the specific mitophagy markers, PINK1 and PARKIN, in the bodily fluids of Japanese patients with MS, NMOSD and myelin oligodendrocyte glycoprotein antibody disorders (MOGAD). Here, PRKN is linked to myeloid sarcoma.