SOCS1 patients may present with Hyper IgE-like syndrome (HIES) with eczema and purulent infections, P1 had a HIES score of 48 (25) (Table 1, Table S2 and Figures 2C, D), eosinophilic allergic alveolitis (EAA) in P2 (Table 1 and Figures 2C, E) as well as common variable immunodeficiency (CVID)-like phenotype with hypogammaglobulinemia, T-cell lymphopenia and granulomatous lymphocytic interstitial lung disease (GLILD) in P3 (Table 1, Table S1 and Figures 2C, E). Here, SOCS1 is linked to hyper-IgE syndrome.