In 2021, Kheum et al. reported that a combinatorial immunotherapy consisting of anti-PD-1/anti-CTLA-4/anti-LAG-3 was less effective in obese mice fed a Western Diet than in age-matched lean controls on standard diet in both the B16 melanoma and MC38 colon carcinoma models (28). The gene discussed is CTLA4; the disease is melanoma.