This study found that OS was significantly improved in patients with obesity who had PD-L1+ tumors (HR = 0.36 [95% CI, 0.21-0.62] for patients within the highest PD-L1 expression category), but that OS was not influenced by BMI in PD-L1- tumors (Table 1). Here, CD274 is linked to obesity due to melanocortin 4 receptor deficiency.