Furthermore, anti-CD3/anti-CD28 stimulation of T cells in bulk peripheral blood mononuclear cell (PBMC) preparations resulted in heightened interferon γ (IFNγ) secretion in donors with obesity, despite the fact that fewer CD8+ T cells and CD56+ NK cells were present (29). The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.