CD4 and obesity due to melanocortin 4 receptor deficiency: One caveat to these transcriptomic data is that flow cytometric analysis of a second cohort of treatment-naive renal tumors (n = 7 normal weight RCC patients and n= 16 RCC patients with obesity) by Sanchez et al. identified no changes in the frequency of any leukocyte population examined (i.e. CD4 T cells, CD8 T cells, B cells, Tregs, neutrophils, dendritic cells), although mast cells were unfortunately not analyzed (32).