KRT88P and infection: As indicated previously, examination of PBMC provides an advantage for OBI detection, particularly its seronegative form, i.e., HBsAg, anti-HBc, and anti-HBs negative (Raimondo et al., 2019), as it was documented for POI in the woodchuck-WHV infection model (Coffin and Michalak, 1999; Gujar and Michalak, 2009; Mulrooney-Cousins et al., 2014; Mulrooney-Cousins and Michalak, 2015).