Although there is no research on rs11168287 polymorphisms and NAFLD, we found that rs11168287 is situated in the peak of H3k4me1 and near the peak of transcription levels by searching the UCSC genome browser (https://genome.ucsc.edu), which means that rs11168287 mutation might affect the serum VD level and its biological effects including insulin sensitivity, lipid metabolism as well as immune inflammation by dysregulating the transcription and expression of VDR gene, and ultimately affect the risk of NAFLD. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.