The interest in therapies targeting tau goes beyond AD as other severely debilitating neurodegenerative disorders such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), frontotemporal lobar degeneration (FTLD), argyrophilic grain disease, and globular glial tauopathy are also characterized by abnormal deposition of tau protein in the brain (46). Here, MAPT is linked to argyrophilic grain disease.