After sequence coding familial PD and atypical parkinsonism-associated genes including GBA, SNCA, VPS35, LRRK2, GCH1, PRKN, PINK1, DJ-1, VPS13C, and ATP13A2 and correcting for multiple comparisons, burden and SKAT-O analyses did not show an association of any of the tested genes and PD. The gene discussed is SNCA; the disease is Parkinson disease.