Thus, in the present study, we first examined the changes in the intestinal barrier and neuroinflammation in mice with HF caused by ligation of the left anterior descending coronary artery (LAD), then analyzed their relationship by the intestinal barrier protector intestinal alkaline phosphatase (IAP) and intestinal homeostasis inhibitor L-phenylalanine (L-Phe), and further explored the underlying mechanism in TLR4-knockout mice. This evidence concerns the gene TLR4 and hydrops fetalis.