APLNR and hypertensive disorder: Additionally, we have shown increased aplnr expression in the SFO of SHRs [an established and well-characterized model of hypertension (Trippodo and Frohlich, 1981)] in comparison to control Wistar Kyoto (WKY) rats (Griffiths et al., 2020), providing evidence of a likely association for SFO APJ in the pathogenesis of hypertension in the SHR.