Concurrently the pro-fibrotic effect of TGF-β1 was abolished by significant reduction of GFP (+) F4/80 (+) α-SMA (+) bone marrow-derived macrophages undergoing macrophage-myofibroblast transformation (MMT) (Wang et al., 2017) and thereby kidney fibrosis was reduced in the murine model of unilateral ureteral obstruction (UUO) (Yang et al., 2019). Here, ACTA1 is linked to Ureteral obstruction.