IRF1 and urogenital neoplasm: Similarly, miR-30c-5p agomir which directly inhibits Interferon regulatory factor 1 (IRF1) reduced kidney ischemic injury by reducing M1 macrophages and increasing of M2 macrophages, and by reducing inflammatory cytokine TNF-α and increasing anti-inflammatory cytokines IL-4 and IL-10 (Zhang et al., 2019; Guo et al., 2020).