TGFB1 and hepatocellular carcinoma: Additionally, isoviolanthin (71) was revealed to suppress transforming growth factor (TGF)-β1-induced EMT through the regulation of TGF-β/Smad and PI3K/Akt/mTOR signaling pathways in HepG2 and Bel-7402 hepatocellular carcinoma (HCC) cells (Xing et al., 2018).