IGHE and asthma: Asthma is thought to be a Th2 cell-associated inflammatory disease, and Th2-type cytokines, such as IL-4 and IL-13, which can activate B cells to produce allergen-specific IgE, are considered to drive disease pathology in patients (Lu et al., 2016; Elieh Ali Komi and Grauwet, 2018).