NFKB1 and cancer: Research hotspots related to these drugs have focused on the mechanisms of anti-cancer, including anti-inflammatory (Rodríguez-Luna et al., 2019), protection against DNA damage (Boss et al., 2016), anti-metastatic (Syed Najmuddin et al., 2016), regulation signaling pathways (such as NF-κB, COX-2, and STAT signaling) (Perng et al., 2016; Song et al., 2017; Narożna et al., 2020), suppression of cell migration and modulation of lncRNA expression (Zhang et al., 2018), etc. Thus, these natural products may become potential clinical anti-tumor drugs in the future.