INPP5A and cerebellar degeneration: Deletion of INPP5A leads to PCs degeneration and ataxia in mice and contributes to cerebellar degeneration in Spinocerebellar ataxia type 17 (SCA17) mice, whereas overexpression of INPP5A in the cerebellum ameliorated PCs degeneration in SCA17 knock-in mice (Yang et al., 2015; Liu et al., 2020).