Deletion of INPP5A leads to PCs degeneration and ataxia in mice and contributes to cerebellar degeneration in Spinocerebellar ataxia type 17 (SCA17) mice, whereas overexpression of INPP5A in the cerebellum ameliorated PCs degeneration in SCA17 knock-in mice (Yang et al., 2015; Liu et al., 2020). The gene discussed is INPP5A; the disease is spinocerebellar ataxia type 17.