TRIM32 and early-onset autosomal dominant Alzheimer disease: In addition, TRIM32 participated in many CNS-related diseases, including Alzheimer's disease (Yokota et al., 2006), autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) (Lionel et al., 2011, 2014; Zhu et al., 2019), anxiety and obsessive compulsive disorder (Lionel et al., 2014).