TRIM32 and autosomal recessive limb-girdle muscular dystrophy type 2H: TRIM32 regulates myofibrillar protein turnover in physiological situation, and TRIM32 mutant disrupts the ability to degrade dysbindin (Locke et al., 2009) and actin (Cohen et al., 2012) by ubiquitination, which ultimately leads to Limb-gridle muscular dystrophy type 2H (LGMD2H), a characteristic with muscular dystrophic changes and motor dysfunction (Shieh et al., 2011).