A striking example of such a transition is the role of proteins of the VPS family (VPS24, VPS28, and VPS60) in reducing the toxicity of alpha-synuclein by controlling the sorting of proteins in the Golgi complex during the formation of endosomes and prevacuoles, which was first revealed in a yeast model (Liang et al., 2008) and was later confirmed by the detection of mutations in the gene encoding the VPS35 protein (a homolog of the yeast VPS35 protein) in one of the familial monogenic forms of PD, PARK17 (Vilariño-Güell et al., 2011; Zimprich et al., 2011; Ando et al., 2012). This evidence concerns the gene SNCA and Parkinson disease.