Stroke elicits robust inflammatory reactions, and microglia are among the very first brain cells to react to the ischemic pathological changes, by responding to various damage-associated molecular patterns (DAMPs) released from the injured cells, such as adenosine, heat shock proteins, high mobility group box 1, and interleukin-33 (IL-33) (Shi et al., 2019). This evidence concerns the gene IL33 and stroke disorder.