Kozlowska et al. (2013) confirmed an interaction between miR-214 and the 3′-UTR of Htt. While wtHtt did not affect miR-214 or β-catenin expression, mHtt mediated β-catenin downregulation by upregulating miR-214 (Ghatak and Raha, 2018). HSF1-regulated miR-214 expression can suppress mHTT aggregation in an HD cell model (Das and Bhattacharyya, 2015). Bucha et al. (2015) showed that increased miR-214 expression in HD cells could target mitofusin2 (MFN2), thereby altering mitochondrial morphology and deregulating the cell cycle. The gene discussed is HSF1; the disease is Huntington disease.