RPPH1 and Alzheimer disease: Gu et al. (2020b) have demonstrated that both lncRNA RPPH1 and miR-122 were up-regulated in an AD mouse model, and that lncRNA RPPH1 activated Wnt/β-catenin signaling, thus ameliorating Aβ induced neuronal apoptosis in SK-N-SH cells via direct targeting of miR-122.