Expression of the lncRNA MEG3 has been found to be down-regulated in an Aβ25–35 induced AD rat model by Yi et al., who have suggested that MEG3 up-regulation improved memory and spatial learning abilities, decreased Aβ deposition in the hippocampus, and mitigated oxidative stress and inflammatory injury by inactivating the phosphatidylinositol 3-kinase and protein kinase B (PI3K/AKT) pathway in this model (Yi et al., 2019). This evidence concerns the gene MEG3 and Alzheimer disease.