TUG1 and Alzheimer disease: Li X. et al. (2020) have observed that TUG1 expression was up-regulated in an AD mouse model, whereas TUG1 knockdown improved memory and spatial learning ability, decreased pathological neuronal injury, and inhibited neuronal apoptosis by elevating miR-15a levels and suppressing Rho-associated kinase 1 (ROCK1) expression in an AD mouse model.