HAGLROS regulates autophagy and apoptosis in MPP+ induced SH-SY5Y cells by sponging miR-100, whereas up-regulated HAGLROS appears to contribute to PD development by inhibiting apoptosis and autophagy, effects that might be achieved through regulation of the miR100/ATG10 axis and PI3K/AKT/mTOR pathway (Peng et al., 2019). This evidence concerns the gene AKT1 and Parkinson disease.