Smailovic et al. (2019) reported microstate B coverage negatively associated with the Aβ42 level in patients with AD (mean age 68 y), but with low Spearman’s rank coefficient. The associations with Aβ42 level were also observed in other classes (Smailovic et al., 2019). The current study demonstrated a stronger correlation between microstate and CSF biomarkers in patients with EOAD. CSF Aβ42 and tau have high diagnostic accuracy. Here, MAPT is linked to Alzheimer disease.