After adjusting these confounders, the effect of rs10994336 polymorphism on methylation of the CpG site cg02172182 within the gene body of ANK3 was observed in HC and replicated in patients with BD in the same direction where the risk T-allele carriers presented a reduced methylation relative to homozygous CC participants, suggesting that the effect of genotype on methylation is not driven by the disease and rs10994336 could be referred to as a reliable meQTL. Here, ANK3 is linked to Behcet disease.