Knowng that immune cell infiltration in the tumor microenvironment (TME) may affect the immunotherapy efficacy and the subsequent outcome of ccRCC patients, we examined DDX39 expression and found a positive correlation with B, CD4+T cell and CD8+T cell, macrophage, neutrophil and dendritic cell infiltration in the data downloaded from TIMER database (Figure 8A). The gene discussed is CD4; the disease is nonpapillary renal cell carcinoma.