Recently, miR-125a has been reported as a tumor suppressor that was significantly downregulated in multiple cancer types, such as non-small cell lung cancer 38, gastric cancer 39, bladder cancer 40, etc. In our study, BRD4 was predicted as the candidate target gene of miR-125a by Targetscan and was verified by dual-luciferase reporter assay. The gene discussed is BRD4; the disease is non-small cell lung carcinoma.