Recently, bioinformatics analysis revealed that ZC3H13 and KIAA1429 could be practical and reliable prognostic indicators of HCC 29; however, the molecular mechanisms of ZC3H13 in the RAS-ERK pathway and their interactions in HCC have not been fully elucidated, therefore further researches are needed to be conducted in the future. The gene discussed is MAPK1; the disease is hepatocellular carcinoma.