The studies of AOM+DSS mice and clinical samples CRC and the analysis of TCGA bioinformatics database in this study showed that ELTD1 expression was notably upregulated in CRC and correlated with lymph node metastasis and poor prognosis; these results suggest that ELTD1 can be used as a prognostic marker for CRC. The gene discussed is ADGRL4; the disease is colorectal carcinoma.